GLP-1 family: tracking semaglutide, tirzepatide, and the broader class
The GLP-1 (glucagon-like peptide-1) class has become the largest single category in the peptide tracking space, driven by semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) for weight management. Both require strict weekly titration, careful side-effect monitoring, and long-term marker tracking — exactly what Peptra is built for.
Compounds in this category
Why GLP-1 tracking is different
Other peptide protocols are typically constant-dose for a fixed cycle. GLP-1s are titrated — your dose increases over weeks, sometimes over months. The schedule is rigid (manufacturer-defined) but real-world deviations are common: holding at a dose longer because of side effects, stepping down if a higher dose becomes intolerable, pausing during major life events.
Tracking has to handle:
- Weekly cadence with the right reminder window for each user
- Titration progression (auto or manual)
- Weight as the primary outcome marker
- Side-effect severity scoring (nausea, fatigue, constipation, sulfur burps)
- Hydration and protein intake for muscle preservation at higher doses
Quick comparison
| Semaglutide | Tirzepatide | |
|---|---|---|
| Mechanism | GLP-1 agonist | GLP-1 + GIP dual agonist |
| Brand names | Ozempic, Wegovy, Rybelsus | Mounjaro, Zepbound |
| Weekly dose range | 0.25 – 2.4 mg | 2.5 – 15 mg |
| Titration steps | 5 | 6 |
| Time to maintenance | ~17 weeks | ~21 weeks |
| Average weight loss (clinical trial, max dose, 72 wk) | ~14.9% | ~22.5% |
| FDA approval (weight loss indication) | 2021 (Wegovy) | 2023 (Zepbound) |
The Peptra titration scheduler
Both compounds ship with their manufacturer titration schedule pre-loaded. You can:
- Auto-advance: Peptra moves you to the next dose at the scheduled week
- Manual advance: stay at a dose as long as you choose, advance when ready
- Step-down: drop back one rung if needed
- Custom protocol: define your own cadence if you and your clinician are deviating
What to track on GLP-1s
- Weight, weekly at the same time and conditions
- Side effects: nausea, fatigue, constipation, sulfur burps, indigestion — score 0-3 for severity
- Appetite: subjective scale, useful for knowing when to titrate up vs hold
- Protein intake: critical at higher doses to preserve lean mass
- Sleep quality: changes during titration are common
Related reading
- GLP-1 titration schedule: semaglutide vs tirzepatide compared
- Tirzepatide vs semaglutide titration speed
- Reconstitution calculator (handles GLP-1 mg dosing)
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Disclaimer
Peptra is a personal tracking tool. It does not provide medical advice. GLP-1 agonists are prescription medications in the US, EU, and most jurisdictions. Use only with appropriate clinical supervision. References to brand names (Ozempic, Wegovy, Mounjaro, Zepbound) are factual; we are not affiliated with the manufacturers.